Does the dose influence in African Swine Fever have something to teach us about HHV-6 dose influence in AIDS and Chronic Fatigue Syndrome?

 Influence of Age and Dose of African Swine Fever Virus Infections on Clinical Outcome and Blood Parameters in Pigs | Viral Immunology (liebertpub.com)


African swine fever (ASF) is a fatal disease for domestic pigs, leading to serious economic losses in countries where ASF is endemic. Despite extensive research, efficient vaccines against ASF are lacking. Since peripheral blood cells are important mediators for vaccines, we study the impact of ASF on blood parameters in pigs with different ages and infected with different doses of ASF virus. Four different groups were studied: (1) 12 weeks of age/low virus dose; (2) 12 weeks of age/high virus dose; (3) 18 weeks of age/low virus dose; and (4) 18 weeks of age/high virus dose. By varying in age and/or ASFV inoculation dose, we monitor blood parameters during different degrees of disease. Thirty percent of the pigs survived the infection with a moderately virulent strain of African swine fever virus (ASFV). Animals that did survive infection were generally older, independent from the inoculation dose used. A firm reduction in many different cell types at 3–5 days postinfection (DPI) was accompanied by an increase in body temperature, followed by clinical signs and mortality from day 6 PI. While blood parameters generally normalized in survivors, γδ T cells and IL-10 levels could be related to mortality. These conclusions should be considered in new approaches for protection against ASF.

Popular Posts in the Last 7 Days

Perplexity A.I. on AIDS as an in silico Ponzi scheme

Bees, AIDS and African Swine Fever Virus: John Beldekas talks about AIDS and African Swine Fever Virus

How Mary Guinan's incompetence and cognitive bias led to the Chronic Fatigue Syndrome cover-up.

Perplexity on Rebecca Culshaw Smith and Fauci's original thinking about AIDS

Perplexity on multifactorialism and Peter Duesberg

The big question for French scientists and intellectuals:

Perplexity on the issue of endogenous versus exogenous retroviruses. Is this a key to the HIV mistake?

Who will be the first researcher to officially connect Chronic Fatigue Syndrome to Kaposi's Sarcoma?

Popular Post in the Last 30 Days

Perplexity on multifactorialism and Peter Duesberg

A Perplexity A.I. Editorial about HHV-6

Perplexity A.I. wrote this op-ed about Rebecca Culshaw's Substack

Is Chronic Fatigue Syndrome Associated Kaposi's Sarcoma (CFSKS) a diagnosis all doctors should become aware of?

Has Maureen Hanson found another opportunistic infection that links Chronic Fatigue Syndrome and AIDS?

HHV-8 which is found in AIDS and Chronic Fatigue Syndrome may be an Arbovirus. Are HHV-6 and HHV-7 arboviruses? Is Kaposi's Sarcoma spread by ticks?

Perplexity on Rebecca Culshaw's critics.

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

Why HIV should be referred to as "a red herring."

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?