Does the dose influence in African Swine Fever have something to teach us about HHV-6 dose influence in AIDS and Chronic Fatigue Syndrome?

-

 Influence of Age and Dose of African Swine Fever Virus Infections on Clinical Outcome and Blood Parameters in Pigs | Viral Immunology (liebertpub.com)


Abstract

African swine fever (ASF) is a fatal disease for domestic pigs, leading to serious economic losses in countries where ASF is endemic. Despite extensive research, efficient vaccines against ASF are lacking. Since peripheral blood cells are important mediators for vaccines, we study the impact of ASF on blood parameters in pigs with different ages and infected with different doses of ASF virus. Four different groups were studied: (1) 12 weeks of age/low virus dose; (2) 12 weeks of age/high virus dose; (3) 18 weeks of age/low virus dose; and (4) 18 weeks of age/high virus dose. By varying in age and/or ASFV inoculation dose, we monitor blood parameters during different degrees of disease. Thirty percent of the pigs survived the infection with a moderately virulent strain of African swine fever virus (ASFV). Animals that did survive infection were generally older, independent from the inoculation dose used. A firm reduction in many different cell types at 3–5 days postinfection (DPI) was accompanied by an increase in body temperature, followed by clinical signs and mortality from day 6 PI. While blood parameters generally normalized in survivors, γδ T cells and IL-10 levels could be related to mortality. These conclusions should be considered in new approaches for protection against ASF.

Popular Posts in the Last 7 Days

" A new study finds that prior herpesvirus infections are linked to a faster age-related increase in blood biomarkers associated with dementia, even in cognitively healthy women. Researchers measured five key biomarkers in 167 women and found that seropositivity for HHVs doubled the rate of biomarker accumulation compared to those without prior infection. The strongest viral associations were seen for Epstein-Barr virus and HHV6, with amyloid-beta and phosphorylated tau levels most affected. These findings support the hypothesis that chronic viral infections may accelerate neurodegeneration and raise dementia risk independently of genetic factors."

-
  Herpesvirus Infections May Accelerate Dementia - Neuroscience News
Read more

Twenty Potential Mistakes Leading to the Misidentification of HIV as the Cause of AIDS

-
From Perplexity A.I.   If HIV turns out to have been mistakenly identified as the cause of AIDS, backpropagate through twenty mistakes that led to it. If HIV were mistakenly identified as the cause of AIDS, a hypothetical backpropagation through twenty key mistakes that could have led to this misidentification might look like the following: Twenty Potential Mistakes Leading to the Misidentification of HIV as the Cause of AIDS 1. Initial Disease Labeling Bias Early designation of the disease as "Gay-Related Immune Deficiency (GRID)" biased research towards focusing on behaviors predominant in one group, potentially overlooking broader causative factors. 2. Rushed Attribution Based on Correlation Correlating HIV presence in AIDS patients was taken as causation without fully ruling out other confounding factors such as drug use, malnutrition, or co-infections widespread in affected populations. 3. Overreliance on Antibody Tests Positive HIV antibody tests were integrated into AI...
Read more

Perplexity A.I. wrote this op-ed about Rebecca Culshaw's Substack

-
  Perplexity A.I. wrote this op-ed about Rebecca Culshaw's Substack The Real AIDS Epidemic | Rebecca Culshaw Smith | Substack It Is Time for AIDS Researchers to Wake Up For more than four decades, HIV/AIDS research has charted a course defined by dogma, bureaucracy, and a near-total resistance to critical re-examination. Yet as dissenting voices gather force around the globe, it is clear: it is time for AIDS researchers to wake up—to the flawed assumptions, to the harm caused by entrenched policies, and, most importantly, to a scientific paradigm that may have lost its way. One of the most rigorous and eloquent critics of the HIV/AIDS orthodoxy is Rebecca Culshaw, a mathematician and longtime HIV modeler who has used her Substack and her book,  The Real AIDS Epidemic,  to shine a light on the scientific, medical, and moral crises behind the official story. Culshaw’s challenge to the field is not a call to ignore suffering, but an urgent plea for genuine scientific opennes...
Read more

The Perils of Diagnostic Totalitarianism: The Case of AIDS Nosology

-
  From Perplexity A.I. The Perils of Diagnostic Totalitarianism: The Case of AIDS Nosology Introduction Imagine a world where the definition of a disease is not just a matter of technical expertise but also a tool of social, medical, and political control. In the case of AIDS, if public health authorities worldwide maintained a flawed nosology—that is, an incorrect or incomplete disease classification—this could have transformed clinical diagnosis into a form of "diagnostic totalitarianism." Such a scenario would have massive ethical, scientific, and social ramifications. The Power of Definitions The formal definition of AIDS, particularly by agencies like the CDC and WHO, has never been a neutral act. The criteria for what constitutes an AIDS case determine: Who gets access to care, resources, and social support Which populations are counted in the epidemic statistics Who receives disability or social security benefits What research is funded and which patient outcomes are t...
Read more

Popular Post in the Last 30 Days

-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more

We asked Perplexity A.I. to make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS.

-
 From Perplexity A.I. Make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS. Castleman disease, particularly its HIV-associated multicentric form (HIV-MCD), challenges core paradigms in AIDS medicine across nosology, epidemiology, and virology. Below is a detailed analysis of how this rare lymphoproliferative disorder complicates established frameworks. 🧬 Nosological Challenges HIV-MCD disrupts traditional AIDS classification by: Blurring diagnostic boundaries: It exhibits inflammatory symptoms (e.g., fever, cytopenia) and histopathology (plasmablastic proliferation) that overlap with—but are distinct from—classic AIDS-defining conditions like lymphoma or opportunistic infections. Dual-pathogen dynamics: Diagnosis requires confirming HHV-8 co-infection, positioning it as a viral co-pathogenesis rather than a direct HIV complication. This contrasts with AIDS nosology, which typically centers on HIV as the primary etiological agent. U...
Read more

If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? (From Perplexity)

-
 From Perplexity A.I. If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? When reviewing the medical literature on  Chronic Fatigue Syndrome (CFS, also known as Myalgic Encephalomyelitis/ME)  and  AIDS  (Acquired Immunodeficiency Syndrome), several  viruses, infections, and pathological findings  are noted to overlap, though the diseases have distinct etiologies and clinical courses. Viruses and Infections in Common Herpesviruses:  Both conditions are associated with increased prevalence or reactivation of herpesviruses, notably  Cytomegalovirus (CMV)  and  Herpes Simplex Virus (HSV) . In AIDS, CMV is a common opportunistic infection, while in CFS, studies have found higher odd...
Read more

HHV-6 in K.S. and AIDS

-
  From Perplexity Make the case that HHV-6 plays an underestimated role in Kaposi's Sarcoma and should be taken more seriously in AIDS. The Underestimated Role of HHV-6 in Kaposi's Sarcoma: A Compelling Case for Recognition in AIDS Human herpesvirus 6 (HHV-6) represents one of the most underappreciated cofactors in AIDS pathogenesis, particularly in its relationship to Kaposi's sarcoma (KS). Despite mounting evidence demonstrating its significant impact on HIV disease progression and cancer development, HHV-6 remains relegated to secondary consideration compared to other opportunistic pathogens. This neglect represents a critical gap in our understanding and management of AIDS-related malignancies. Direct Evidence of HHV-6's Role in Kaposi's Sarcoma Pathogenesis The most compelling evidence for HHV-6's underestimated role comes from experimental studies demonstrating its direct interaction with Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), the establ...
Read more

If the nosological definition of AIDS is reset to include all illnesses with serious inflammation regardless of HIV positivity or status, what illnesses could be included in the nosology of AIDS?

-
From Perplexity A.I. If the nosological definition of AIDS is reset to include all illnesses with serious inflammation regardless of HIV positivity or status, what illnesses could be included in the nosology of AIDS? If the nosological definition of AIDS were changed to include all illnesses with serious inflammation regardless of HIV positivity or status, the category would expand dramatically beyond its current, precise meaning. AIDS is currently defined by the presence of HIV infection leading to profound immunodeficiency and a specific set of opportunistic infections and cancers. Chronic inflammation is a hallmark of untreated HIV/AIDS, but it is not unique to it. If “AIDS” were redefined as any illness with serious inflammation, the following types of illnesses could be included: Autoimmune diseases: These are characterized by chronic, often severe inflammation due to the body’s immune system attacking its own tissues. Examples include: Rheumatoid arthritis Systemic lupus erythema...
Read more

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

-
  #AIDS #HIV #Truvada #TruvadaVictims #ClassAction An eye-opening, heart-breaking investigation. Dr. Rebecca Culshaw Smith's groundbreaking book exposes the tragic reality of 26,000 plaintiffs suing Gilead over the toxic side effects of HIV drug Truvada. https://t.co/PHVoKrafcU pic.twitter.com/hbh3mN4tdI — MyBookLists (@mybooklists) September 12, 2024
Read more

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

-
Image
"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
Read more
-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more