Do altered endothelial dysfunction-related miRs in plasma link AIDS and Chronic Fatigue Syndrome?

-

 

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by unexplained debilitating fatigue. Although the etiology is unknown, evidence supports immunological abnormalities, such as persistent inflammation and immune-cell activation, in a subset of patients. Since the interplay between inflammation and vascular alterations is well-established in other diseases, endothelial dysfunction has emerged as another player in ME/CFS pathogenesis. Endothelial nitric oxide synthase (eNOS) generates nitric oxide (NO) that maintains endothelial homeostasis. eNOS is activated by silent information regulator 1 (Sirt1), an anti-inflammatory protein. Despite its relevance, no study has addressed the Sirt1/eNOS axis in ME/CFS. The interest in circulating microRNAs (miRs) as potential biomarkers in ME/CFS has increased in recent years. Accordingly, we analyze a set of miRs reported to modulate the Sirt1/eNOS axis using plasma from ME/CFS patients. Our results show that miR-21, miR-34a, miR-92a, miR-126, and miR-200c are jointly increased in ME/CFS patients compared to healthy controls. A similar finding was obtained when analyzing public miR data on peripheral blood mononuclear cells. Bioinformatics analysis shows that endothelial function-related signaling pathways are associated with these miRs, including oxidative stress and oxygen regulation. Interestingly, histone deacetylase 1, a protein responsible for epigenetic regulations, represented the most relevant node within the network. In conclusion, our study provides a basis to find endothelial dysfunction-related biomarkers and explore novel targets in ME/CFS.


Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients (nih.gov)

Popular Posts in the Last 7 Days

Is the CDC one stop closer to admitting Chronic Fatigue Syndrome is part of the HHV-6/AIDS epidemic?

-
Image
Tweet https://www.meaction.net/2018/07/29/cdc-revises-its-information-on-me/ If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                                                In his bestsell...
Read more

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

-
Image
  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
Read more

Time for action on HHV-6! Please post and circulate:

-
The HHV-6 Rights of Man 1. The right not to be lied to about the role of HHV-6 in AIDS. 2. The right not to be lied to about the role of HHV-6 in Chronic Fatigue Syndrome. 3. The right not to be lied to about the role of HHV-6 in Autism. 4.The right not to be lied to about the role of HHV-6 in Multiple Sclerosis. 5. The right not to be lied to about the role of HHV-6 in Brain Cancer. 6. The right not to be lied to about the role of HHV-6 in Heart Disease. 7. The right not to be lied to about the role of HHV-6 in Encephalitis. 8. The right not to be lied to about the role of HHV-6 in Cognitive Dysfunction. 9. The right not to be lied to about the role of HHV-6 in Drug Hypersensitivity Syndrome. 10. The right not to be lied to about the role of HHV-6 in Bone Marrow Suppression. 11. The right not to be lied to about the role of HHV-6 in Lymphadenopathy.  12. The right not to be lied to about the role of HHV-6 in Colitis. 13. The rig...
Read more

HHV-6A and HHV-6B are actually different species

-
http://jvi.asm.org/cgi/content/full/73/10/8040?view=full&pmid=10482553 If HHV-6 is the real cause of AIDS, here are some of the implications: 1. HIV is a massive scientific fraud. Something akin to a Ponzi scheme. Scientists who challenged the HIV theory of AIDS (the ones who have been thuggishly censored and silenced) turn out to be on the money. 2. Chronic Fatigue Syndrome and Autism (and many other so-called HHV-6 related mysterious epidemics) are part of the so-called AIDS epidemic.  Chronic Fatigue Syndrome and Autism both are clearly the results of the ravages of HHV-6. 3. AIDS and Chronic Fatigue Syndrome has been artificially and politically separated into two epidemics. We are living in a period of CFS/AIDS apartheid. So-called AIDS patients have to sit in the back of the HHV-6 epidemic bus while the befuddled HHV-6/CFS patients and HHV-6/Autism victims sit up front. Nobody is well-served. 4. AIDS is not a sexually transmitted disease. That p...
Read more

HHV-6 is fun for everyone 24/7!

-
"Again, the main obstacle comes from the fact that HHV-6 infection occurs early in life, is nearly universal, and is lifelong." Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections Henri Agut    Pascale Bonnafous    Agnès Gautheret-Dejean Clin Microbiol Rev. 2015 Apr;28(2):313-35. doi: 10.1128/CMR.00122-14. http://cmr.asm.org/content/28/2/313.full.pdf+html?ijkey=v5.FkAKXOuEoU&keytype=ref&siteid=asmjournals If HHV-6 is the real cause of AIDS, here are some of the implications: 1. HIV is a massive scientific fraud. Something akin to a Ponzi scheme. Scientists who challenged the HIV theory of AIDS (the ones who have been thuggishly censored and silenced) turn out to be on the money. 2. Chronic Fatigue Syndrome and Autism (and many other so-called HHV-6 related mysterious epidemics) are part of the so-called AIDS epidemic.  Chronic Fatigue Syndrome and Autism both are clearly the results of the ravages of HHV-6. 3. AIDS ...
Read more

HHV-6 is both "ubiquitous" and "remarkable."

-
Image
Tweet Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections "Generally speaking, the formal demonstration of the causative role of HHV-6 in many acute and chronic human diseases is difficult due to the ubiquitous nature of the virus, chronicity of infection, existence of two distinct species, and limitations of current investigational tools. The antiviral compounds ganciclovir, foscarnet, and cidofovir are effective against active HHV-6 infections, but the indications for treatment, as well as the conditions of drug administration, are not formally approved to date. There are still numerous pending questions about HHV-6 which should stimulate future research works on the pathophysiology, diagnosis, and therapy of this remarkable human virus" http://cmr.asm.org/content/28/2/313.abstract If you have Amazon Prime or Kindle Unlim...
Read more

Popular Post in the Last 30 Days

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

-
Image
  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
Read more

Time for action on HHV-6! Please post and circulate:

-
The HHV-6 Rights of Man 1. The right not to be lied to about the role of HHV-6 in AIDS. 2. The right not to be lied to about the role of HHV-6 in Chronic Fatigue Syndrome. 3. The right not to be lied to about the role of HHV-6 in Autism. 4.The right not to be lied to about the role of HHV-6 in Multiple Sclerosis. 5. The right not to be lied to about the role of HHV-6 in Brain Cancer. 6. The right not to be lied to about the role of HHV-6 in Heart Disease. 7. The right not to be lied to about the role of HHV-6 in Encephalitis. 8. The right not to be lied to about the role of HHV-6 in Cognitive Dysfunction. 9. The right not to be lied to about the role of HHV-6 in Drug Hypersensitivity Syndrome. 10. The right not to be lied to about the role of HHV-6 in Bone Marrow Suppression. 11. The right not to be lied to about the role of HHV-6 in Lymphadenopathy.  12. The right not to be lied to about the role of HHV-6 in Colitis. 13. The rig...
Read more

Is the CDC one stop closer to admitting Chronic Fatigue Syndrome is part of the HHV-6/AIDS epidemic?

-
Image
Tweet https://www.meaction.net/2018/07/29/cdc-revises-its-information-on-me/ If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                                                In his bestsell...
Read more

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

-
 From Perplexity A.I.  If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event? If the scientific establishment were to fundamentally revise the current understanding of AIDS and declare that HIV is not the cause, this would indeed constitute a Black Swan event—an extremely rare, unpredictable, and highly consequential occurrence that dramatically alters conventional wisdom and scientific consensus. A Black Swan event is defined by its rarity, profound impact, and the tendency for people to rationalize it retrospectively as if it could have been expected. The current scientific consensus, established in the late 1980s and reinforced by overwhelming evidence, is that HIV is the causative agent of AIDS. This consensus is based on decades of research, clinical experience, and the effectiveness of HIV-targeting treatments. If the establishment were to reverse this consensus, it would be unpreceden...
Read more

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more
-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

-
Image
"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
Read more

Why HIV should be referred to as "a red herring."

-
 From Perplexity A.I. Make the case that the critics of the HIV theory of AIDS would be more effective at their messaging to politicians and the public by constantly referring to HIV as a red herring. Critics of the HIV theory of AIDS—those who argue that HIV is not the causative agent of AIDS—often struggle to convey their message effectively to politicians and the public because the scientific consensus firmly upholds the link between HIV and AIDS. However, from a communications strategy perspective, such critics might amplify the clarity and urgency of their argument by consistently describing HIV as a "red herring." Here’s why this tactic could make their messaging more effective: 1. Framing the Narrative Labeling HIV as a "red herring" frames the dominant scientific focus on the virus as a distraction from finding the true cause of AIDS (as the critics would argue). This concise phrase presents the debate in terms of misdirection, which is an accessible and com...
Read more

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more