Bhupesh Prusty and his colleagues have nailed it. Will the AIDS and Chronic Fatigue Syndrome establishment finally admit that HHV-6 is a problem that has to be dealt with?




Tissue specific signature of

 HHV-6 infection in ME/CFS

First exposure to various human herpesviruses (HHVs) including HHV-6, HCMV and EBV does not cause a life-threatening disease. In fact, most individuals are frequently unaware of their first exposure to such pathogens. These herpesviruses acquire lifelong latency in the human body where they show minimal genomic activity required for their survival. We hypothesized that it is not the latency itself but a timely, regionally restricted viral reactivation in a sub-set of host cells that plays a key role in disease development. HHV-6 (HHV-6A and HHV-6B) and HHV-7 are unique HHVs that acquire latency by integration of the viral genome into sub-telomeric region of human chromosomes. HHV-6 reactivation has been linked to Alzheimer’s Disease, Chronic Fatigue Syndrome, and many other diseases. However, lack of viral activity in commonly tested biological materials including blood or serum strongly suggests tissue specific localization of active HHV-6 genome. Here in this paper, we attempted to analyze active HHV-6 transcripts in postmortem tissue biopsies from a small cohort of ME/CFS patients and matched controls by fluorescence in situ hybridization using a probe against HHV-6 microRNA (miRNA), miR-aU14. Our results show abundant viral miRNA in various regions of the human brain and associated neuronal tissues including the spinal cord that is only detected in ME/CFS patients and not in controls. Our findings provide evidence of tissue-specific active HHV-6 and EBV infection in ME/CFS, which along with recent work demonstrating a possible relationship between herpesvirus infection and ME/CFS, provide grounds for renewed discussion on the role of herpesviruses in ME/CFS.

Popular Posts in the Last 7 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV

If one assume Rebecca Culshaw's Substack is correct, what were 20 moments in the last 40 ears when scientist should have recognized something was wrong in the HIV/AIDS paradigm?

Perplexity on the irony of debunking David Ho's HIV research

From Perplexity: Here are 20 ways the pharmaceutical industry should reorient their AIDS efforts based on Rebecca Culshaw’s Substack critique of the HIV paradigm:

New cartoon

Popular Post in the Last 30 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

From Perplexity: A list of 20 things Rebecca Culshaw could say to a new generation of AIDS doctors and scientists to get them to go back to ground zero in 1981, start from scratch, and rethink everything about AIDS including the nosology, the epidemiology, causation, the virology, the demonization of critics, the demonization and scapegoating and criminalization of patients.

Perplexity on the Nosology of AIDS

Perplexity on David Ho

Perplexity on Rebecca Culshaw, AIDS and CFS

Perplexity on the AIDS paradigm

From Perplexity: Here are 20 ways the pharmaceutical industry should reorient their AIDS efforts based on Rebecca Culshaw’s Substack critique of the HIV paradigm:

New cartoon

Perplexity on the implications of Rebecca Culshaw Smith's critique of HIV

Perplexity A.I. on the potential impact of Rebecca Culshaw Smith

Popular Posts from the Last Year

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Why HIV should be referred to as "a red herring."

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?