Bhupesh Prusty and his colleagues have nailed it. Will the AIDS and Chronic Fatigue Syndrome establishment finally admit that HHV-6 is a problem that has to be dealt with?




Tissue specific signature of

 HHV-6 infection in ME/CFS

First exposure to various human herpesviruses (HHVs) including HHV-6, HCMV and EBV does not cause a life-threatening disease. In fact, most individuals are frequently unaware of their first exposure to such pathogens. These herpesviruses acquire lifelong latency in the human body where they show minimal genomic activity required for their survival. We hypothesized that it is not the latency itself but a timely, regionally restricted viral reactivation in a sub-set of host cells that plays a key role in disease development. HHV-6 (HHV-6A and HHV-6B) and HHV-7 are unique HHVs that acquire latency by integration of the viral genome into sub-telomeric region of human chromosomes. HHV-6 reactivation has been linked to Alzheimer’s Disease, Chronic Fatigue Syndrome, and many other diseases. However, lack of viral activity in commonly tested biological materials including blood or serum strongly suggests tissue specific localization of active HHV-6 genome. Here in this paper, we attempted to analyze active HHV-6 transcripts in postmortem tissue biopsies from a small cohort of ME/CFS patients and matched controls by fluorescence in situ hybridization using a probe against HHV-6 microRNA (miRNA), miR-aU14. Our results show abundant viral miRNA in various regions of the human brain and associated neuronal tissues including the spinal cord that is only detected in ME/CFS patients and not in controls. Our findings provide evidence of tissue-specific active HHV-6 and EBV infection in ME/CFS, which along with recent work demonstrating a possible relationship between herpesvirus infection and ME/CFS, provide grounds for renewed discussion on the role of herpesviruses in ME/CFS.

Popular Posts in the Last 7 Days

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

Can one make the case that the nosology of AIDS involves circular reasoning about HIV positivity?

How did 50% of Chronic Fatigue Syndrome patients become infected with a cancer virus?

Important and provocative books about HHV-6 and the epidemics it may be causing available from Amazon in print editions or on Kindle:

Suppose the real cause of AIDS is X and X is also found in Chronic Fatigue Syndrome. What are the possibilities of what X is?

Popular Post in the Last 30 Days

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

We asked Perplexity A.I. to make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS.

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

Are any endogenous retroviruses reactivated in AIDS and do any of them act like superantigens?

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

Is African Swine Fever a threat to human health in Congo?

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?