HERV-K18 seems to turn AIDS and CFS into superantigen syndromes. Here is what you need to know about HERV-K.

 Human endogenous retrovirus K - Wikipedia

HHV-6A infection induces expression of HERV-K18-encoded superantigen - PubMed (nih.gov)

HHV-6A infection induces expression of HERV-K18-encoded superantigen

Affiliations 

Abstract

Background: The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein-Barr virus (EBV) infection and IFN-alpha treatment.

Objectives: Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies.

Study design: HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT-PCR.

Results: Latently infected HSB2-ML cells showed a significant increase in HERV-K18 RNA compared to the control cells. HERV-K18 expression was even greater in HSB2 cells productively infected with HHV-6A for 78h.

Conclusion: These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-alpha that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed.

Popular Posts in the Last 7 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

Paul Cheney on Chronic Fatigue Syndrome and AIDS

How did 50% of Chronic Fatigue Syndrome patients become infected with a cancer virus?

HHV-6 and Inflammation

One way of looking at HHV-6

The story of the newspaper that uncovered the truth about Chronic Fatigue Syndrome.

Why isn't China testing its pigs in Wuhan and Hubei for SARS-CoV-2? This experiment is beating around the bush.

Popular Post in the Last 30 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

Is the CDC hiding the HHV-8 epidemic in the gay community? Does it reveal that HIV is a big mistake?

Perplexity was asked to develop a concept of "policed gratitude" or "enforced gratitude" that has been imposed on AIDS patients to keep them in line and believing all the public health directions they are given.

Perplexity A.I. on "Duesberg Derangement Syndrome"

August 28, 2016 HHV-6 University Cartoon

Kaposi's Sarcoma may still prove HIV is not the cause of AIDS.

Advance praise for RFK Jr.'s forthcoming book on Anthony Fauci

Popular Posts from the Last Year

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Why HIV should be referred to as "a red herring."

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?