Is the role of HHV-6 in Chronic Fatigue Syndrome (and AIDS) about to become settled science?

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Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | ImmunoHorizons

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Philipp Schreiner, Thomas Harrer, Carmen Scheibenbogen, Stephanie Lamer, Andreas Schlosser, Robert K. Naviaux and Bhupesh K. Prusty
ImmunoHorizons April 1, 2020, 4 (4) 201-215; DOI: https://doi.org/10.4049/immunohorizons.2000006

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disorder with many possible triggers. Human herpesvirus (HHV)–6 and HHV-7 are two infectious triggers for which evidence has been growing. To understand possible causative role of HHV-6 in ME/CFS, metabolic and antiviral phenotypes of U2-OS cells were studied with and without chromosomally integrated HHV-6 and with or without virus reactivation using the histone deacetylase inhibitor trichostatin-A. Proteomic analysis was conducted by pulsed stable isotope labeling by amino acids in cell culture analysis. Antiviral properties that were induced by HHV-6 transactivation were studied in virus-naive A549 cells challenged by infection with influenza-A (H1N1) or HSV-1. Mitochondria were fragmented and 1-carbon metabolism, dUTPase, and thymidylate synthase were strongly induced by HHV-6 reactivation, whereas superoxide dismutase 2 and proteins required for mitochondrial oxidation of fatty acid, amino acid, and glucose metabolism, including pyruvate dehydrogenase, were strongly inhibited. Adoptive transfer of U2-OS cell supernatants after reactivation of HHV-6A led to an antiviral state in A549 cells that prevented superinfection with influenza-A and HSV-1. Adoptive transfer of serum from 10 patients with ME/CFS produced a similar fragmentation of mitochondria and the associated antiviral state in the A549 cell assay. In conclusion, HHV-6 reactivation in ME/CFS patients activates a multisystem, proinflammatory, cell danger response that protects against certain RNA and DNA virus infections but comes at the cost of mitochondrial fragmentation and severely compromised energy metabolism.



From the University of Wurzburg:


"While HHV-6 was long believed to have no negative impact on human health, scientists today increasingly suspect the virus of causing various diseases such as multiple sclerosis or chronic fatigue syndrome. Recent studies even suggest that HHV-6 might play a role in the pathogenesis of several diseases of the central nervous system such as schizophrenia, bipolar disorder, depression or Alzheimer's."




 Thanks to Bhupesh Prusty, the search for the cause of Chronic Fatigue Syndrome may soon be over.

 Has Bhupesh Prusty found a promising treatment for HHV-6 and Chronic Fatigue Syndrome?

The Chronic Fatigue Syndrome and HHV-6 Scientist of the Year 

 Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

 Will Bhupesh Prusty add more evidence that HHV-6 is the cause of Chronic Fatigue Syndrome?

 "Bhupesh Prusty is determining if HHV-6 infections are hampering mitochondrial functioning in ME/CFS."

 Chronic Fatigue Syndrome activist's 2018 research summary leaves out HHV-6 and the work of Bhupesh Prusty


The Chronic Fatigue Syndrome and HHV-6 Scientist of the Year 

 Meet the scientist who may prove that HHV-6 is the Chronic Fatigue Syndrome virus


Why is the Chronic Fatigue Syndrome community ignoring the biggest breakthrough? 

 Breaking news about Dr. Prusty's game-changing HHV-6 & Chronic Fatigue Syndrome research from the University of Wurzburg 

 The major Chronic Fatigue Syndrome organization is supporting the scientist who may show HHV-6 is the cause of Chronic Fatigue Syndrome. 
The Prusty study of HHV-6 in Chronic Fatigue Syndrome that Solve ME/CFS supported.

 Does the research of Bhupesh Prusty support the theory that HHV-6 is causing oxidative stress in AIDS & CFS?

 If Bhupesh Prusty wins a Nobel Prize for proving HHV-6 is the cause of Chronic Fatigue Syndrome, will he share it with Gallo or Beldekas?

 Chronic Fatigue Syndrome patients are finally discovering Prusty's CFS and HHV-6 research  



Want to know the history of the cover-up of the role of HHV-6 in Chronic Fatigue Syndrome and AIDS? This book takes you back to the beginning.


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