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Wednesday, November 26, 2014

HHV-6 University Cartoons

HHV-6 University Cartoons

CFS and HHV-6 Books on Kindle Unlimited



These two unique books about CFS and HHV-6 are available on Kindle Unlimited.

The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition]

A collection of cartoons about the cover-up of the Chronic Fatigue Syndrome epidemic. Anyone who knows the whole sorry story about the Chronic Fatigue Syndrome epidemic will tell you that it is one of the great tragedies in world history. A syndrome with so many similarities to AIDS that it has been called "AIDS Minor," CFS has been swept under the rug for three decades while millions of people have seen every aspect of their lives ruined. Patients have trouble deciding whether the government scientists in charge of researching it are liars or just plain stupid and incompetent. In other word,s CFS is the perfect subject for the pen of a caustic satirist. Cartoonist Julian Lake has used his sharp wit to capture the absurdities of a vast epidemic that has been hidden in plain sight by medical authorities who have put the whole world at risk. But sufferers of CFS are no different from the victims of any other political injustice. They may have have been lied to and may have had to live with compromised immune systems, but they haven't lost their sense of humor. There are times in the darkest chapters of history when one just has to laugh. This collection of often hilarious, uncompromising cartoons will garner smiles of recognition from anyone who has any familiarity with the crazy, ugly story of Chronic Fatigue Syndrome and the outrageous attempts to cover it up. The cartoons in this collection are like drones that never miss their targets.

The Closing Argument

"Ortleb's courageous and tireless investigative journalism (starting with his work as publisher @ NY Native Newspaper back in the 1980s') is second-to-none. While I generally prefer reading non-fiction over fiction, this novel leaves you jaw-dropped. It is clear that Ortleb is scientifically, well-researched in the field of CFS/AIDS, and understands the pandemic from its inception. Once again, Ortleb pushes the envelope with The Closing Argument --- moving humanity forward"

Brigitte Huber on HERV-18 as CFS Risk Factor (and encoder of superantigen)



"HERV-K18 causes massive T-Cell activation" 

"Superantigen wreaks havoc in the immune system?"





















































HHV-6A infection induces expression of HERV-K18-encoded superantigen

 http://www.sciencedirect.com/science/article/pii/S1386653209001942

Description of Brigitte Huber's 2010 CFS Research Project:

 HERVK-18 AS RISK FACTOR FOR CFIDS

DESCRIPTION (provided by applicant): The etiology of Chronic Fatigue Syndrome (CFS) is far from understood and is likely due to multiple genetic components. Infection with EBV and treatment with IFN-a have been implicated in the pathogenesis. Our laboratory has shown that EBV-infection, and exogenous IFN-a?, activate transcription of the env gene of a Human Endogenous Retrovirus, HERV-K18. This provirus is normally silent, but when induced it encodes a superantigen (SAg), which is a class of proteins that is capable of deregulating the immune system. Three alleles of HERV-K18 env have been documented, K18.1, K18.2, K18.3, whose gene products have SAg activity, but are predicted to differ biochemically and functionally. Our working hypothesis is that HERV-K18 is a risk factor for CFS. In a pilot study, the allele and genotype distributions of the HERV-K18 env gene were compared between various groups of CFS patients and healthy controls. Although only a limited number of samples were available in the various cohorts, the odds ratios that were obtained were statistically significant. The most intriguing interpretation of these data are that they provide genetic evidence for the unique etiology of at least one group of CFS patients. Thus, it may be possible to delineate different subtypes of CFS, depending on the clinical history of the patients. It is now proposed to substantiate these pilot results, using a much larger cohort of 400 CFS patients associated with EBV that has been assembled by the co-investigator, Dr. Renee Taylor. Dr. Ben Katz, board certified in both Pediatrics and Pediatric Infectious Diseases, will clinically evaluate the patient cohort, and Dr. Inga Peter, a genetic epidemiologist and biostatistician, will oversee the statistical analyses. In addition, the expression pattern of the HERV-K18 SAg during active disease versus intermission will be measured. Furthermore, T cell stimulatory activity of this SAg, expressed on peripheral blood lymphocytes of patients during the course of the disease, will be tested ex vivo, using a T cell hybridoma reporter assay that has been developed in our lab. Since SAg-activated T cells produce massive quantities of chemokines, lymphokines and neurokines, the expression of the HERV-K18 SAg could influence not only the immune system, but other organs as well. A positive association between CFS and either HERV-K18 alleles or expression patterns would open new avenues for the development of clinical treatments of this chronic disease. CFS is a disease that affects a significant number of people worldwide, yet the underlying mechanism(s) of pathogenesis remains unclear. The herpesvirus EBV and IFN-a have been suggested to be associated with CFS, although these concepts are far from accepted. We propose a novel genetic aspect in the EBV/ CFS association, namely the presence of certain HERV-K18 alleles that differ in their superantigen activity
 http://projectreporter.nih.gov/project_info_description.cfm?projectnumber=5R01AR053821-04

HHV-6 and Dendritic Cells

 Dendritic cells.jpgDendritic cell revealed.jpg

 Dendritic cells (DCs) are antigen-presenting cells, (also known as accessory cells) of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems.

Source: http://en.wikipedia.org/wiki/Dendritic_cell

Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells

"OBJECTIVE:Monocyte-derived dendritic cells (DCs) play important roles in the immune response against infections and malignancies. Human herpesvirus 6 (HHV-6) infects monocytes and is reactivated in immunodeficient patients. To clarify the mechanisms of HHV-6-induced immunodeficiency, we investigated the effect of HHV-6 infection on differentiation of monocytes to DCs."

http://www.ncbi.nlm.nih.gov/pubmed/16647570

Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection.

"The present data also suggest that the dysfunction of HHV-6-infected DCs is attributable mainly to impairment of the antigen capture and intracellular antigen-processing pathways."

http://www.ncbi.nlm.nih.gov/pubmed/12239310

 

 

 

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