HHV-6 University

http://www.sciencedirect.com/science/article/pii/S1386653214004545

Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA).   http://www.ncbi.nlm.nih.gov/pubmed/25427994   Abstract The objectives of this study were to gather information regarding demographic and clinical characteristics of patients diagnosed with either fibromyalgia (FM) or chronic fatigue (CFS) following hepatitis B vaccination (HBVv) and furthermore to apply the recently suggested criteria of autoimmune (auto-inflammatory) syndromes induced by adjuvants (ASIA), in the aim of identifying common characteristics that may suggest an association between fibromyalgia, chronic fatigue and HBV vaccination. Medical records of 19 patients with CFS and/or fibromyalgia following HBVv immunization were analyzed. All of which were immunized during 1990-2008 in different centers in the USA. All medical records were evaluated for demograph...

Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea http://www.biomedcentral.com/1471-2334/14/630/abstract

HHV-6 University Cartoons

These two unique books about CFS and HHV-6 are available on Kindle Unlimited. The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition] A collection of cartoons about the cover-up of the Chronic Fatigue Syndrome epidemic. Anyone who knows the whole sorry story about the Chronic Fatigue Syndrome epidemic will tell you that it is one of the great tragedies in world history. A syndrome with so many similarities to AIDS that it has been called "AIDS Minor," CFS has been swept under the rug for three decades while millions of people have seen every aspect of their lives ruined. Patients have trouble deciding whether the government scientists in charge of researching it are liars or just plain stupid and incompetent. In other word,s CFS is the perfect subject for the pen of a caustic satirist. Cartoonist Julian Lake has used his sharp wit to capture the absurdities of a vast epidemic that has been hidden in plain sight by medi...

"HERV-K18 causes massive T-Cell activation"  "Superantigen wreaks havoc in the immune system?" HHV-6A infection induces expression of HERV-K18-encoded superantigen  http://www.sciencedirect.com/science/article/pii/S1386653209001942

 HERVK-18 AS RISK FACTOR FOR CFIDS DESCRIPTION (provided by applicant): The etiology of Chronic Fatigue Syndrome (CFS) is far from understood and is likely due to multiple genetic components. Infection with EBV and treatment with IFN-a have been implicated in the pathogenesis. Our laboratory has shown that EBV-infection, and exogenous IFN-a?, activate transcription of the env gene of a Human Endogenous Retrovirus, HERV-K18. This provirus is normally silent, but when induced it encodes a superantigen (SAg), which is a class of proteins that is capable of deregulating the immune system. Three alleles of HERV-K18 env have been documented, K18.1, K18.2, K18.3, whose gene products have SAg activity, but are predicted to differ biochemically and functionally. Our working hypothesis is that HERV-K18 is a risk factor for CFS. In a pilot study, the allele and genotype distributions of the HERV-K18 env gene were compared between various groups of CFS patients and healthy contr...

    Dendritic cells (DCs) are antigen-presenting cells , (also known as accessory cells ) of the mammalian immune system . Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems . Source: http://en.wikipedia.org/wiki/Dendritic_cell Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells "OBJECTIVE:Monocyte-derived dendritic cells (DCs) play important roles in the immune response against infections and malignancies. Human herpesvirus 6 (HHV-6) infects monocytes and is reactivated in immunodeficient patients. To clarify the mechanisms of HHV-6-induced immunodeficiency, we investigated the effect of HHV-6 infection on differentiation of monocytes to DCs." http://www.ncbi.nlm.nih.gov/pubmed/16647570 Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection. ...

    Cartoons about an epidemic of lies. Available November 30! A collection of cartoons about the cover-up of the Chronic Fatigue Syndrome epidemic. Anyone who knows the whole sorry story about the Chronic Fatigue Syndrome epidemic will tell you that it is one of the great tragedies in world history. A syndrome with so many similarities to AIDS that it has been called "AIDS Minor," CFS has been swept under the rug for three decades while millions of people have seen every aspect of their lives ruined. Patients have trouble deciding whether the government scientists in charge of researching it are liars or just plain stupid and incompetent. In other word,s CFS is the perfect subject for the pen of a caustic satirist. Cartoonist Julian Lake has used his sharp to capture the absurdities of a vast epidemic that has been hidden in plain sight by medical authorities who have put the whole world at risk. But sufferers of CFS are no different from the victims of a...

Times finally acknowledges changes in the brains of CFS patients. http://well.blogs.nytimes.com/2014/11/24/brains-of-people-with-chronic-fatigue-syndrome-offer-clues-about-disorder/?partner=rss&emc=rss&_r=1

" Both intrauterine and sexual transmission of human herpesvirus ( HHV)-6 and HHV-7 have been suggested." http://www.ncbi.nlm.nih.gov/pubmed/17922393 " Transmission of this virus is believed to occur as a result of exposure to saliva." http://www.emergingworlds.com/ch_viruses_detail.cfm?vPageid=41  " Human herpesvirus 6 ( HHV - 6 ) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV - 6 DNA."   http://www.ncbi.nlm.nih.gov/pubmed/15170644 " HHV-6 has a very high prevalence (close to 100% of the world’s population has been exposed). It is transmitted mainly by saliva. Transmission occurs usually within the first two years of life; primary infection is often associated with a febrile condition and sometimes with the onset of roseola (exanthem subitum). Two variants of the virus are known, HHV-6A and HHV-6B. HHV-6 is mainly lymphotropic, infecting a broad rang...

Our HHV-6 Pandemic Cartoons

Posts on HHV-6 and Endogenous Retroviruses

Posts On HHV-6 and the Thyroid

 Great article on Salon from Alternet P.S. A multisystemic pandemic of HHV-6 doesn't help.

http://www.morgellons.org/case_definition.htm

http://en.wikipedia.org/wiki/Glioblastoma_multiforme  "Glioblastoma has been associated with the viruses HHV-6 , and cytomegalovirus."

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If you like this cartoon you'll love this hilarious little book. The Chronic Fatigue Syndrome Follies [Paperback]  http://www.amazon.com/The-Chronic-Fatigue-Syndrome-Follies/dp/product-description/0966345487

Epidemiology of Herpes Human Virus 6 and 7 Infections in Salivary Gland Neoplasms in Isfahan, Iran http://www.academia.edu/7979518/Epidemiology_of_Herpes_Human_Virus_6_and_7_Infections_in_Salivary_Gland_Neoplasms_in_Isfahan_Iran "HHV-6 and the HHV-7 have been identified as one of the most im portant oncogenic viruses "

http://sciencenordic.com/first-image-irritable-bowel

http://books.google.com/books?id=aEUkBAAAQBAJ&pg=PA128&lpg=PA128&dq=hhv+-6+microbiome&source=bl&ots=i76kTibOxb&sig=VLcvOuJ7PtGRC0T6Ect1ukPmMb4&hl=en&sa=X&ei=9rxuVN_KG4yigwTngYP4AQ&ved=0CCAQ6AEwAA#v=onepage&q=hhv%20-6%20microbiome&f=fals e HHV-8 and Chronic Fatigue Syndrome Prevalence in the cerebrospinal fluid of the following infectious agents in a cohort of 12 CFS subjects: human herpes virus-6 and 8; chlamydia species; mycoplasma species; EBV; CMV; and Coxsackievirus. Levine, S. Journal of Chronic Fatigue Syndrome, 2001, 9, 1/2, 41-51. Abstract: Over the last decade a wide variety of infectious agents have been associated with the CFS as potential etiologies for this disorder. Many of these agents are neurotrophic and have been linked previously to other diseases involving the central nervous system (CNS). Human herpes virus-6 (HHV-6), especially the B variant, has been found in autopsy specimens of patients who suffered f...

http://stonebird.co.uk/experience/paralysis.html

New oral medication, PRID-201, shows promise in treating fibromyalgia http://www.news-medical.net/news/20141118/New-oral-medication-shows-promise-in-treating-fibromyalgia.aspx  "Many herpes viruses are known to significantly upregulate COX enzymes in the body, which in turn are important for efficient viral replication," Pridgen said. "In theory, physical or emotional stress in patients can reactivate the virus and result in perpetuation of the symptoms of fibromyalgia. Effectively suppressing latent viruses may significantly improve the pain and related symptoms of FM."  

Abstract To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy) (n = 16) and complex febrile seizures associated with HHV-6 (HHV-6 complex FS) (n = 10). We also examined changes in CSF-8OHdG and CSF-HEL levels in patients with HHV-6 encephalopathy before and after treatment with edaravone, a free radical scavenger. CSF-8-OHdG levels in HHV-6 encephalopathy and HHV-6 complex FS were significantly higher than in control subjects. In contrast, CSF-HEL levels showed no significant difference between groups. The levels of total tau protein in HHV-6 encephalopathy were significantly higher than in control subjects. ...

http://www.slate.com/articles/health_and_science/medical_examiner/2014/11/glenn_beck_says_he_has_adrenal_fatigue_that_s_not_a_real_medical_condition.html

The Chronic Fatigue Syndrome Follies [Paperback]  http://www.amazon.com/The-Chronic-Fatigue-Syndrome-Follies/dp/product-description/0966345487

http://www.empr.com/endo-approved-for-generic-valcyte/article/382267/ Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue. http://www.ncbi.nlm.nih.gov/pubmed/17276366   Response to valganciclovir in chronic fatigue syndrome patients with human herpesvirus 6 and Epstein-Barr virus IgG antibody titers.   Valganciclovir treatment, independent of the baseline antibody titers, was associated with self-rated improvement in physical and cognitive functioning for CFS patients who had positive HHV-6 and/or EBV serologies. Longer valganciclovir treatment correlated with an improved response.  http://www.ncbi.nlm.nih.gov/pubmed/23080504  

Parents risk transmitting diseases to their children through excessive physical intimacy "Yang said that two other common viruses transferred to children via saliva were HHV-6 and HHV-7, which typically affect all human beings before the age of two. In most cases, the viruses result in a sudden fever and a rash, although in rare cases, the child may also experience from febrile convulsions - a mild epileptic seizure after which a child will return to normal"  http://www.globaltimes.cn/content/892431.shtml

http://www.news.gov.tt/content/african-swine-fever-ebola-can-we-win-battle-control-infectious-disease#.VGtL3slsjw0

Learn more: http://www.naturalnews.com/047675_MMR_vaccine_CDC_fraud_Andrew_Wakefield.html?#ixzz3JQXCUcdg

http://7thspace.com/headlines/498653/global_burden_of_deaths_from_epstein_barr_virus_attributable_malignancies_1990_2010.html

The Virus Within by Nicholas Regush (Print Edition) What Really Killed Gilda Radner? Frontline Reports on the Chronic Fatigue Syndrome Epidemic by Neenyah Ostrom (Print Edition) 50 Things You Should Know About the Chronic Fatigue Syndrome Epidemic by Neenyah Ostrom (Print Edition) America's Biggest Cover-Up: 50 More Things Everyone Should Know About the Chronic Fatigue Syndrome Epidemic And Its Link to AIDS by Neenyah Ostrom (Print Edition) The Closing Argument by Charles Ortleb (Available on Kindle and in a Print Edition. Free for Kindle owners with Amazon Prime.)

http://emedicine.medscape.com/article/219019-clinical

http://www.amazon.com/Plague-Scientist%C2%92s-Intrepid-Retroviruses-Syndrome/dp/1626365652

'Human Endogenous Retroviruses and AIDS Research: Confusion, Consensus, or Science?' (.pdf file) (2010)

http://www.amazon.com/Plague-Scientist%C2%92s-Intrepid-Retroviruses-Syndrome/dp/1626365652

We reported a very rare case of pityriasis rosea with multiple gigantic herald plaques after influenza vaccination. In a state of altered immunity, reactivation of HHV-6 and/or HHV-7 could result through a T-cell-mediated skin-oriented reaction in an atypical presentation of a self-limited suberythrodermic gigantic pityriasis rosea.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025149/

 The Scientific World Journal Volume 2013 (2013), Article ID 867389, 7 pages http://dx.doi.org/10.1155/2013/867389 Review Article Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease In the recent years, several reports have provided important information linking HHV-6A/B to autoimmune diseases (AD) including multiple sclerosis [1–7], autoimmune connective tissue diseases [8–11], and Hashimoto’s thyroiditis [12]. In addition, it has been suggested that HHV-6A/B infection might be related to the onset of autoimmune disorders, including Sjogren’s syndrome [13], purpura fulminans, severe autoimmune acquired protein S deficiency [14], severe and acute autoimmune hepatitis [15, 16], and autoimmune hemolytic anemia/neutropenia [17] http://www.hindawi.com/journals/tswj/2013/867389/

 "Contamination can also waste valuable time and money and, when it applies to medical research, create false hope for patients. The most egregious recent example involved a virus called XMRV, which was touted as a possible cause of chronic fatigue syndrome (CFS), after a 2009 paper identified it in samples from CFS patients. After a long saga involving much follow-up work , allegations of misconduct, the retraction of the original paper , and much angst for patients, it is now clear that XMRV was a contaminant." http://phenomena.nationalgeographic.com/2014/11/11/contaminomics-why-some-microbiome-studies-may-be-wrong/

http://www.theatlantic.com/health/archive/2014/11/study-gives-mysterious-chronic-fatigue-syndrome-some-legitimacy/382617/

http://www.mdlinx.com/cardiology/news-article.cfm/5722919/?xml European Journal of Heart Failure, 11/12/2014  Clinical Article Kühl U, et al. – Human herpesvirus 6 (HHV–6) A and B are two betaherpesviruses that are associated with many conditions including roseola, drug–induced hypersensitivity syndrome, limbic encephalitis, and myocarditis. The data suggest that virus replication in cardiac tissue of ciHHV–6 heart failure patients suggests that ciHHV–6 reactivation causes persistence of unexplained heart failure symptoms. The authors demonstrated that antiviral treatment, effective in decreasing viral transcripts and clinical complaints of cardiomyopathies, is a new therapeutic option for ciHHV–6–associated diseases. 

http://www.theepochtimes.com/n3/1074276-has-ebola-already-mutated-to-evade-detection/

More info on pets with CFS.

PLHV-1 and -2 are highly homologous to each other but not to PLHV-3. The two viruses are widespread in domestic pigs and are closely related to several ruminant gammaherpesviruses, most of which are etiologically implicated in the occurrence of malignant catarrhal fever (MCF), a lymphoproliferative inflammatory disease with an often fatal outcome. PLHV-1 and -2 are also related to Epstein-Barr Virus, Human Herpesvirus-8 and other gammaherpesviruses. http://www.zoologix.com/zoo/Datasheets/PorcineLymphotropicHerpesvirus.htm

 Analysis of Porcine Cytomegalovirus DNA Polymerase by Consensus Primer PCR https://www.jstage.jst.go.jp/article/jvms/61/11/61_11_1253/_pdf Sequencing data on the PCR product confirmed that Porcine CMV is a betaherpesvirus, and suggested that it is most closely related to HHV-6 and HHV-7.

http://www.ncbi.nlm.nih.gov/pubmed/20692426 Abstract Porcine organs are valuable candidate materials for xenotransplantation to humans. Long-term maintenance of well functioning transplants is a prerequisite for success. Transplanted organs may be damaged by immune reactions or by infectious agents in hosts. Human herpesviruses (HHVs) establish life-long latency in humans after a primary infection. They can be reactivated with various stimuli, including immunosuppression. This study was performed to verify the infectivity of some HHVs toward porcine cells. PK-15 cells infected with HHV-1 and HHV-2 showed cytopathology from 1 day after infection. Immunofluorescent (IF) staining of HHV-1- and HHV-2-infected PK-15 cells with respective antibodies demonstrated the expression of the respective viral antigens. Permissiveness of PK-15 to HHV-1 and -2 was confirmed by an infection test on Vero cells. Islet cells infected with HHV-5 showed no gross morphologic changes during t...

  portal.volkswagenstiftung.de/search/projectPDF.do?projectId=2443 Human herpesvirus-6 (HHV-6) achieves latency by integrating into human genome. Can activation of integrated HHV-6 shorten telomeres and cause unstable telomeric ends that contribute to disease? Can activated, partial or full-length viral genome reintegrate into human chromosome or is it lost completely? Can latent or activated HHV-6 influence the host cell through partial transcription or translation? Preliminary data shows that chromosomally integrated HHV-6 is not always silent. Common drugs and environmental exposure can activate it . Whole or parts of viral genome can shuffle in and out of host chromosomes resulting in genomic instability. Further, the "semi-latent" virus is functionally active enough to influence cells without forming infectious viral particles. Over 95% of human population carry latent HHV-6/-7 that can get activated while exposed to specific, timely, relevant triggers. Hence, it migh...

Publication date: December 2014 Source:Current Opinion in Virology, Volume 9 Author(s): Emily C Leibovitch , Steven Jacobson Following reports of elevated antiviral antibodies in MS patient sera and viral DNA detection in MS plaques nearly two decades ago, the neurovirology community has actively explored how herpesviruses such as HHV-6 might be involved in MS disease pathogenesis. Though findings across the field are non-uniform, an emerging consensus of viral correlates with disease course and evidence of HHV-6-specific immune responses in the CNS provide compelling evidence for a role, direct or indirect, of this virus in MS . Ultimately, the only way to demonstrate the involvement, or lack thereof, of HHV-6 or other herpesviruses in this disease is through a controlled clinical trial ... http://www.mschristian.org/msc/index.php/23-ms-news-from-the-web/10494-evidence-linking-hhv-6-with-multiple-sclerosis-an-update

https://ash.confex.com/ash/2014/webprogram/Paper73452.html CONCLUSIONS : This retrospective study confirms a correlation of HHV-6 with high morbidity and mortality rates after alloSCT , thus suggesting a regular HHV-6 monitoring in alloSCT recipients. The regular monitoring of HHV-6 DNA, using a real-time PCR assay, may be useful for identifying active HHV-6 infection and for the introduction of a pre-emptive treatment, possibly reducing the incidence of the most severe clinical complications. Despite HHV-6 detection typically occurred early after alloSCT , a better immune reconstitution has the potential to improve clinical outcome.

"Block non-specific reactivity with pig serum , 1:20 dilution in TBS buffer 10 min and remove buffer by blotting" hhv -6foundation.org/wp.../ HHV - 6HHV -7-IHC-Techniques-Krueger.pdf

This Little Piggy has HHV-6 Is HHV-6 a Human and Porcine Virus? http://vir.sgmjournals.org/content/80/4/971 Abstract Evidence for the existence of porcine gammaherpesviruses was obtained by PCR and sequence analysis. Initially, samples of peripheral blood mononuclear cells (PBMC), spleens, lungs, kidneys and livers of pigs from Germany and Spain were tested with a PCR assay which targets conserved regions of the herpesvirus DNA polymerase gene with degenerate and deoxyinosine-substituted primers. Amplicons of identical sequence were obtained from one spleen and two PBMC samples. This sequence showed a high percentage of identity with the DNA polymerase genes of herpesviruses of the oncogenic subfamily Gammaherpesvirinae. Alignment of amino acid sequences showed the highest identity values with bovine gammaherpesviruses, namely alcelaphine herpesvirus type 1 (...

jgv.sgmjournals.org/content/70/12/3171.full.pdf

"Some regions of HHV-6 are known to share sequence homology with other viruses, such as CMV and HHV-7, which may obscure the specificity of the results." http://jvi.asm.org/content/76/12/6147.full

" Dr. Thomas Glass, a pathologist and dental surgeon at the Oklahoma Health Sciences Center who helped identify victims of the Oklahoma City federal building bombing, has performed studies that appear to show that chronic fatigue syndrome and, therefore, its putative viral cause can be transmitted between humans and their pets ." http://www.me-ireland.com/review.htm Two of the viral isolates were tested by Dr. Tom Glass for the ability to induce disease in cats. The results were quite striking and added considerable weight to the concept of a stealth viral encephalopathy. This work was published in "Pathobiology" http://www.ccid.org/stealth/faq.htm Pets and CFIDS/CFS/ME http://curezone.com/blogs/fm.asp?i=968619 Study 1:The conclusion of this study was that CFIDS patients not only have pets, but that there is a significant animal interaction and that a large number of these animals have atypical or u...